Preoperative Radiotherapy in Myxoid Liposarcoma

Fenny Tjuatja; H M Djakaria

doi:10.32532/jori.v11i2.114

Preoperative Radiotherapy in Myxoid Liposarcoma

Fenny Tjuatja, H M Djakaria

Sari

Myxoid liposarcoma are responsive to radiotherapy, particularly preoperative radiotherapy. The outcome of the preoperative radiation is a decreasing tumor size and major necrotizing area. With a good local control, organ functions can survive without any amputation. Preoperative radiotherapy can be given with or without chemotherapy. Conventional fractionation such as 25 x 2 Gy or hypofractionation 5 x 5 Gy could be an effective way to treat preoperative myxoid liposarcoma.

Kata Kunci

myxoid liposarcoma, preoperative radiotherapy, sarcoma, radiotherapy

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Referensi

Jones RL, Lee ATJ, Thway K, Huang PH. Clinical and molecular spectrum of liposarcoma. J Clin Oncol. 2018;36(2):151–9.

Regina C, Hettmer S, Regina C, Hettmer S. Myxoid liposarcoma : it ’ s a hippo ’ s world OFF. 2019;(April):10–2.

Trautmann M, Menzel J, Bertling C, Cyra M, Altvater B, Isfort I, et al. FUS – DDIT3 Fusion Protein-Driven IGF-IR Signaling is a Therapeutic Target in Myxoid Liposarcoma. 2017;6227–39.

Huh WW, Yuen C, Munsell M, Hayes-Jordan A, Lazar AJ, Patel S, et al. Liposarcoma in children and young adults: A multi-institutional experience. Pediatr Blood Cancer. 2011;57(7):1142–6.

Report C, E BT, Olufemi A, Adeniyi A. Clinical Oncology : Case Reports Myxoid Liposarcoma in a 2 Year old Boy : A Case Report. 2019;2–5.

With AC, Soft O, Sarcomas T. Radiosensitivity Translates Into Excellent Local Control in Extremity Myxoid Liposarcoma. 2009;

Moreau L, Turcotte R, Ferguson P, Wunder J, Clarkson P, Masri B, et al. Myxoid Round Cell Liposarcoma ( MRCLS ) Revisited : An Analysis of 418 Primarily Managed Cases. 2012;1081–8.

Archives A. From the Archives of the AFIP Imaging of Musculoskeletal Liposar- coma with Radiologic-Pathologic OBJECTIVES. 2005;1371–95.

Dürr HR, Rauh J, Baur-melnyk A, Knösel T, Lindner L, Roeder F, et al. Myxoid liposarcoma : local relapse and metastatic pattern in 43 patients. 2018;1–7.

Report C. Myxoid liposarcoma of hypopharynx- A diagnostic and management dilemma. 2018;4(June):57–62.

Antonescu CR, Tschernyavsky SJ, Decuseara R, Leung DH, Woodruff JM, Brennan MF, et al. Prognostic Impact of P53 Status , TLS-CHOP Fusion Transcript Structure , and Histological Grade in Myxoid Liposarcoma : A Molecular and Clinicopathologic Study of 82 Cases 1. 2001;7(December):3977–87.

Graaff MA De, Yu JSE, Beird HC, Ingram DR, Nguyen T, Liu JJ, et al. Establishment and characterization of a new human myxoid liposarcoma cell line ( DL-221 ) with the FUS-DDIT3 translocation. 2016;96(April):885–94.

Salemis NS. Metachronous multifocal myxoid liposarcoma involving the gastrointestinal tract . Management and literature review. 2014;5(1):186–91.

Muratori F, Bettini L, Frenos F, Mondanelli N, Greto D, Livi L, et al. Myxoid Liposarcoma: Prognostic Factors and Metastatic Pattern in a Series of 148 Patients Treated at a Single Institution. Int J Surg Oncol. 2018;2018.

Guadagnolo BA, Zagars GK, Ballo MT, Patel SR, Lewis VO, Benjamin RS, et al. Excellent Local Control Rates and Distinctive Patterns of Failure in Myxoid Liposarcoma Treated With Conservation Surgery and Radiotherapy. Int J Radiat Oncol Biol Phys. 2008;70(3):760–5.

Schwab JH, Boland P, Guo T, Brennan MF, Singer S, Healey JH, et al. Skeletal Metastases in Myxoid Liposarcoma : An Unusual Pattern of Distant Spread. 2007;14(4):1507–14.

Manaster BJ. Soft-Tissue Masses: Optimal Imaging Protocol and Reporting. 2013;(September):505–14.

Sharma S, Kamala R, T RR, Mhatre S, Sabharwal R. Round Cell Tumors : Classification and Immunohistochemistry. 2017;

Lemeur M, Mattei J, Souteyrand P, Chagnaud C, Curvale G, Rochwerger A. Prognostic factors for the recurrence of myxoid liposarcoma : 20 cases with up to 8 years follow-up. Orthop Traumatol Surg Res [Internet]. 2015;101(1):103–7. Available from: http://dx.doi.org/10.1016/j.otsr.2014.09.024

Jagannathan JP, Tirumani SH. Im ag i n g i n So f t Ti ssu e S a rc o m a s : Current Updates. Surg Oncol Clin NA [Internet]. 2016;25(4):645–75. Available from: http://dx.doi.org/10.1016/j.soc.2016.05.002

Rosenthal MH, Howard SA, Jagannathan JP. Myxoid Soft-Tissue Neoplasms: Comprehensive Update of the Taxonomy and MRI Features. 2015;(February):374–85.

Exhibit S. Myxoid Liposarcoma : Appearance at MR Imaging with Histo- logic Correlation 1. 2000;1007–19.

Tateishi U, Hasegawa T, Beppu Y, Kawai A, Satake M, Moriyama N. Prognostic Significance of MRI Findings in Patients with Myxoid-Round Cell Liposarcoma. Am J Roentgenol. 2004;182(3):725–31.

Schenone AD, Luo J, Montgomery L, Morgensztern D, Adkins DR, Van Tine BA. Risk-stratified patients with resectable soft tissue sarcoma benefit from epirubicin-based adjuvant chemotherapy. Cancer Med. 2014;3(3):603–12.

Kim DW, Jee YS. Solitary metastasis of myxoid liposarcoma from the thigh to intraperitoneum: A case report. World J Surg Oncol. 2019;17(1):10–4.

Ratan R, Patel SR. Chemotherapy for Soft Tissue Sarcoma. 2016;(713):1–9.

Judson I, Verweij J, Gelderblom H, Hartmann JT, Schöff P, Blay J, et al. Doxorubicin alone versus intensifi ed doxorubicin plus ifosfamide for fi rst-line treatment of advanced or metastatic soft-tissue sarcoma : a randomised controlled phase 3 trial. 2014;415–23.

Itson GRP, Obinson PHR, Ilke DEW, Andel RITAAK, Hite LAW, Riffin ANMG, et al. RADIATION RESPONSE : AN ADDITIONAL UNIQUE SIGNATURE OF MYXOID LIPOSARCOMA. 2004;60(2):522–6.

Chowdhry V, Goldberg S, Delaney TF, Cote GM, Chebib I, Kim J, et al. Myxoid Liposarcoma : Treatment Outcomes from Chemotherapy and Radiation Therapy. 2018;2018.

Chowdhry VK, Goldberg SI, DeLaney TF, Cote GM, Raskin KA, Bernstein KD. Myxoid Liposarcoma: A Radiosensitive Malignancy. Int J Radiat Oncol [Internet]. 2017;99(2):E751. Available from: http://dx.doi.org/10.1016/j.ijrobp.2017.06.2407

Hoefkens F, Dehandschutter C, Somville J, Meijnders P, Gestel D Van. Soft tissue sarcoma of the extremities : pending questions on surgery and radiotherapy. Radiat Oncol [Internet]. 2016;1–12. Available from: http://dx.doi.org/10.1186/s13014-016-0668-9

Davis AM, Sullivan BO, Turcotte R, Bell R, Catton C, Chabot P, et al. Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma. 2005;75:48–53.

Chen M, Kirsch DG. EClinicalMedicine Safely combining trabectedin with radiotherapy to treat myxoid liposarcoma. EClinicalMedicine [Internet]. 2019;9:5–6. Available from: https://doi.org/10.1016/j.eclinm.2019.03.015

Saponara M, Stacchiotti S, Gronchi A, Saponara M, Stacchiotti S, Gronchi A. Expert Review of Clinical Pharmacology Pharmacological therapies for Liposarcoma Pharmacological therapies for Liposarcoma. Expert Rev Clin Pharmacol [Internet]. 2017;10(4):361–77. Available from: http://dx.doi.org/10.1080/17512433.2017.1289086

Kose H, Haas R, Morysi T. Efficacy of neoadjuvant hypofractionated radiotherapy in patients with locally advanced myxoid liposarcoma. 2016;1–8.

Kose H, Szacht M, Morysi T. Preoperative hypofractionated radiotherapy in the treatment of localized soft tissue sarcomas. 2014;3–9.

Volume 105 Number 1S Supplement 2019 18%. 2019;105(1):2019.

Temple WJ, Temple CLF, Arthur K, Schachar NS, Paterson AHG, Crabtree TS. Prospective Cohort Study of Neoadjuvant Treatment in Conservative Surgery of Soft Tissue Sarcomas. 1997;4(7):586–90.

Salduz A, Alpan B, Valiyev N, Özmen E, İribaş A, Ağaoğlu F, et al. Neoadjuvant radiotherapy for myxoid liposarcomas: Oncologic outcomes and histopathologic correlations. Acta Orthop Traumatol Turc. 2017;51(5):355–61.

Sargos P, Charleux T, Haas RL, Michot A, Llacer C, Vogin G, et al. Pre- and postoperative radiotherapy for extremity soft tissue sarcoma: Evaluation of inter-observer target volume contouring variability among French sarcoma group radiation oncologists. Cancer / Radiother [Internet]. 2018;c(2017). Available from: https://doi.org/10.1016/j.canrad.2017.09.004

Péchoux C Le, Moureau-zabotto L, Llacer C, Ducassou A, Sargos P, Sunyach MP, et al. Radiothérapie des sarcomes des tissus mous de l ’ adulte Radiotherapy of adult soft tissue sarcoma. Cancer / Radiother [Internet]. 2016;20:S235–43. Available from: http://dx.doi.org/10.1016/j.canrad.2016.07.028

Ang DIANW, Osch WAB, Oberge DAR, Inkelstein STEF, Etersen IVYP, Addock MIH, et al. RTOG SARCOMA RADIATION ONCOLOGISTS REACH CONSENSUS ON GROSS TUMOR VOLUME AND CLINICAL TARGET VOLUME ON COMPUTED TOMOGRAPHIC IMAGES FOR PREOPERATIVE RADIOTHERAPY OF PRIMARY SOFT TISSUE SARCOMA OF EXTREMITY IN RADIATION THERAPY ONCOLOGY GROUP STUDIES. 2011;81(4):525–8.

Wang D, Zhang Q, Eisenberg BL, Kane JM, Li XA, Lucas D, et al. J OURNAL OF C LINICAL O NCOLOGY Significant Reduction of Late Toxicities in Patients With Extremity Sarcoma Treated With Image-Guided Radiation Therapy to a Reduced Target Volume : Results of Radiation Therapy Oncology Group RTOG-0630 Trial. 2020;33(20).

Vakilian S, Mbbs CF, Al-suhaibani A, Roberge D. Kinetics of myxoid liposarcoma radiation response and effects on radiation dose delivery. PRRO [Internet]. 2013;3(3):180–5. Available from: http://dx.doi.org/10.1016/j.prro.2012.06.005

Engström K, Bergh P, Cederlund C, Hultborn R, Willen H, Åman P, et al. Irradiation of myxoid / round cell liposarcoma induces volume reduction and lipoma-like morphology. 2009;

Wilke CT, Wilson J, Ogilvie C, Cheng E, Clohisy D, Yuan J, et al. Radiologic and Pathologic Response After Neoadjuvant Radiation Therapy for Myxoid Liposarcoma of the Extremities. Int J Radiat Oncol [Internet]. 2014;90(1):S765. Available from: http://dx.doi.org/10.1016/j.ijrobp.2014.05.2215

Roberge D, Skamene T, Nahal A, Turcotte RE, Powell T, Freeman C. Radiological and pathological response following pre-operative radiotherapy for soft-tissue sarcoma. Radiother Oncol [Internet]. 2010;97(3):404–7. Available from: http://dx.doi.org/10.1016/j.radonc.2010.10.007

Grange F, Seddon BM. Tumour volume changes following pre-operative radiotherapy in borderline resectable limb and trunk soft tissue sarcoma. 2017;c(April 2014).

Harada A, Sumi M, Toshiyasu T, Yoshioka Y, Takazawa Y, Ae K, et al. Palliative Radiation Therapy for Spinal Metastasis from Myxoid Liposarcoma. Int J Radiat Oncol. 2018;102(3):e441.

Choi C, Park JH, Lee CG, Kim HJ, Suh C, Cho J. Successful salvage treatment of myxoid liposarcoma with multiple peritoneal seeding using helical tomotherapy-based intraperitoneal radiotherapy : a case report. BMC Res Notes [Internet]. 2015;8:1–9. Available from: https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-015-1134-8

Vaynrub MAX, Taheri N, Ahlmann ER, Yao C, Fedenko AN, Allison DC, et al. Prognostic Value of Necrosis After Neoadjuvant Therapy For Soft Tissue Sarcoma. 2015;(March 2014):152–7.

Eilber BFC, Rosen G, Eckardt J, Forscher C, Nelson SD, Selch M, et al. Treatment-Induced Pathologic Necrosis : A Predictor of Local Recurrence and Survival in Patients Receiving Neoadjuvant Therapy for High-Grade Extremity Soft Tissue Sarcomas. 2019;19(13):3203–9.

DOI: https://doi.org/10.32532/jori.v11i2.114 <