Kompresi Medula Spinalis akibat Metastasis

Aurika Sinambela, Irwan Ramli

Sari


Sebanyak 5 – 10% pasien kanker akan mengalami kompresi medulla spinalis akibat metastasis (KMSM). Penyakit ini terjadi saat tumor atau fragmen tulang menggeser dan menekan kedudukan medulla dalam kanalis spinalis. Gejala utama adalah nyeri punggung (83-95% pasien), dengan atau tanpa deficit motorik (82% pasien) dan sensorik (50-80% pasien).  Saat ini pencitraan terpilih untuk diagnosis kompresi medulla spinalis adalah MRI dengan kontras. Kondisi ini merupakan salah satu kegawatdaruratan onkologi, yang harus ditatalaksana segera setelah diagnosisnya ditentukan. Modalitas terapi yang tersedia saat ini adalah operasi, radioterapi, dan kortikosteroid. Sepertiga pasien dengan KMSM memiliki kesempatan hidup lebih dari 1 tahun setelah terapi, sehingga tatalaksana yang dipilih harus mempertimbangkan toksisitas dan morbiditas pasca terapi agar tercapai kualitas hidup yang optimal.

Kata Kunci


Radiasi; Radioterapi; Onkologi; Medula Spinalis

Teks Lengkap:

PDF

Referensi


George R, Jeba J, Ramkumar G, Chacko AG, Leng M. Interventions for the treatment of metastatic extradural spinal cord compression in adults. Cochrane Database Syst Rev [Internet]. 2008; (4) : nopagination. Available from: http://www.mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD006716/pdf_fs.html%5Cnhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed8&NEWS=N&AN=2008514380

Al-qurainy R, Collis E. Metastatic spinal cord compression : diagnosis and management. Br J Med [Internet].2016;2539(May):1–7. Available from: http://dx.doi.org/doi:10.1136/bmj.i2539

Laufer I, Rubin DG, Lis E, Cox BW, Stubblefield MD, Yamada Y, et al. The NOMS Framework: Approach to the Treatment of Spinal Metastatic Tumors. Oncologist [Internet]. 2013;18(6):744–51. Available from: http://theoncologist.alphamedpress.org/cgi/doi/10.1634/theoncologist.2012-0293

Schmidt MH, Klimo P, Vronis FD. Metastatic spinal cord compression. J Natl Compr Cancer Netw [Internet]. 2008;3(November):711–9. Available from: http://www.nice.org.uk/nicemedia/pdf/CG75NICEguideline.pdf

Nichols EM, Patchell RA, Regine WF, Kwok Y. Palliation of Brain and Spinal Cord Metastases. In: Halperin EC, Wazer DE, Perez CA, Brady LW, editors. Perez and Brady’s Principles and Practice of Radiation Oncology. 6th ed. Philadelphia: Lippincot Williams & Wilkins; 2013. p. 1766–76.

Ryu S, Maranzano E, Schild SE, Sahgal A, Yamada Y, Hoskin P, et al. International survey of the treatment of metastatic spinal cord compression. J Radiosurgery SBRT [Internet]. 2015;3(3):237–45. Available from: http://proxy.library.lincoln.ac.uk/login?url=http://search.ebscohost.com/login.aspx?direct=true&db=cmedm&AN=29296406&site=ehost-live

Patel DA, Campian JL. Diagnostic and Therapeutic Strategies for Patients with Malignant Epidural Spinal Cord Compression. Curr Treat Options Oncol. 2017;18(9).

Lee SF, Wong FCS, Tung SY. No Ordinary Back Pain: Malignant Spinal Cord Compression. Am J Med [Internet]. 2018; Available from: http://linkinghub.elsevier.com/retrieve/pii/S0002934318301426

Kumar A, Weber MH, Gokaslan Z, Wolinsky J-P, Schmidt M, Rhines L, et al. Metastatic Spinal Cord Compression and Steroid Treatment. Clin Spine Surg. 2017;30(4).

Fox S, Spiess M, Hnenny L, Fourney DR. Spinal Instability Neoplastic Score (SINS): Reliability Among Spine Fellows and Resident Physicians in Orthopedic Surgery and Neurosurgery. Glob Spine J. 2017;7(8):744–8.

Zaidat O., Ruff R. Treatment of spinal epidural metastasis improves patient survival and functional state. Neurlogy. 2002;58(9):1360–6.

Patchell RA, Tibbs PA, Regine WF, Payne R, Saris S, Kryscio RJ, et al. Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: A randomised trial. Lancet. 2005;366(9486):643–8.

Klimo P, Thompson CJ, Kestle JRW, Schmidt MH. A meta-analysis of surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease. Neuro Oncol [Internet]. 2005;7(1):64–76. Available from: http://academic.oup.com/neuro-oncology/article/7/1/64/1148313/A-metaanalysis-of-surgery-versus-conventional

Mannion RJ, Wilby M, Godward S, Lyratzopoulos G, Laing RJC. The surgical management of metastatic spinal disease: Prospective assessment and long-term follow-up. Br J Neurosurg. 2007;21(6):593–8.Ropper AE, Ropper AH. Acute Spinal Cord Compression. N Engl J Med [Internet]. 2017;376(14):1358–69. Available from: http://www.nejm.org/doi/10.1056/NEJMra1516539

Fehlings MG, Nater A, Tetreault L, Kopjar B, Arnold P, Dekutoski M, et al. Survival and clinical outcomes in surgically treated patients with metastatic epidural spinal cord compression: Results of the prospective multicenter AOSpine study. J Clin Oncol. 2016;34(3):268–76.

Iida K, Matsumoto Y, Setsu N, Harimaya K, Kawaguchi K, Hayashida M, et al. The neurological outcome of radiotherapy versus surgery in patients with metastatic spinal cord compression presenting with myelopathy. Arch Orthop Trauma Surg. 2018;138(1):7–12.

Mui WH, Lam TC, Wong FCS, Sze WK. Survival analysis of malignant epidural spinal cord compression after palliative radiotherapy using Tokuhashi scoring system and the impact of systemic therapy. Ann Palliat Med [Internet]. 2017;6(Suppl 2):706–706. Available from: http://apm.amegroups.com/article/view/16291

Appendices. In: Metastatic Spinal Cord Compression: Diagnosis and Management of Patient at Risk of or with Metastatic Spinal Cord Compression. Cardiff: National Collaborating Centre for Cancer; 2008. p. 1–2.

McGee H. Hospice in the Weald Guideline: Malignant

Spinal Cord Compression. 2013;(Appendix 1):1–13.

Maranzano E, Bellavita R, Rossi R, De Angelis V, Frattegiani A, Bagnoli R, et al. Short-course versus split-course radiotherapy in metastatic spinal cord compression: Results of a phase III, randomized, multicenter trial. J Clin Oncol. 2005;23(15):3358–65.

Lee KA, Dunne M, Small C, Kelly PJ, McArdle O, O’Sullivan J, et al. (ICORG 05-03): prospective randomized non-inferiority phase III trial comparing two radiation schedules in malignant spinal cord compression (not proceeding with surgical decompression); the quality of life analysis. Acta Oncol (Madr) [Internet]. 2018;0(0):1–8. Available from: https://doi.org/10.1080/0284186X.2018.1433320

Ryu S, Jin R, Jin JY, Chen Q, Rock J, Anderson J, et al. Pain Control by Image-Guided Radiosurgery for Solitary Spinal Metastasis. J Pain Symptom Manage. 2008;35(3):292–8.

Fog LS, Schut D, Sjøgren P, Aznar MC. The potential role of modern radiotherapy techniques in the treatment of malignant spinal cord compression: a dose planning study. J Radiother Pract [Internet]. 2015;14(4):418–24. Available from: http://www.journals.cambridge.org/abstract_S1460396915000400

Husain ZA, Sahgal A, Chang EL, Maralani PJ, Kubicky CD, Redmond KJ, et al. CNS Oncology Modern approaches to the management of metastatic epidural spinal cord compression. 2017;6:233–43.

Gerszten PC, Burton SA, Ozhasoglu C, Welch WC. Radiosurgery for spinal metastases: clinical experience in 500 cases from a single institution. Spine (Phila Pa 1976). 2007;32(2):193–9.

Cunha MVR, Al-Omair A, Atenafu EG, Masucci GL, Letourneau D, Korol R, et al. Vertebral compression fracture (VCF) after spine stereotactic body radiation therapy (SBRT): Analysis of predictive factors. Int J Radiat Oncol Biol Phys [Internet]. 2012;84(3):e343–9. Available from: http://dx.doi.org/10.1016/j.ijrobp.2012.04.034




DOI: https://doi.org/10.32532/jori.v9i1.65 <

Article metrics

Abstract views : 4398 | views : 5521

Refbacks

  • Saat ini tidak ada refbacks.




  

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.