Preoperative Radiotherapy in Rectal Cancer

Irwan Ramli, - Sudibio, Fitri Anugrah

Sari


Rectal cancer is the third most common types cancer in the world and rank second as a cause of cancer related deaths in 2018. Surgical is the main modality in treatment of rectal cancer, however preoperative radiotherapy significantly reduces local recurrence risk after surgery. At present there are two different schedules of preoperative radiotherapy, short-course preoperative radiotherapy (25 Gy at 5 fractions)  followed by immediate surgery and long-course chemoradiotherapy (45-50 Gy at 25-28 fractions) followed by delayed surgery. Although the purpose and local control rate of both schedules is the same, it is indicated in different conditions.

 


Kata Kunci


Rectal cancer, preoperative, radiotherapy, short-course radiotherapy, long-course radiotherapy, chemoradiation, radiation

Teks Lengkap:

PDF (English)

Referensi


Bray F, Ferlay J, Soerjomataram I. Global Cancer Statistics 2018 : GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. 2018;00(00):1–31.

Valentini V, Schmoll H. Multidisciplinary Management of Rectal Cancer. 2nd ed. Valentini V, Schmoll H, editors. Multidisciplinary Management of Rectal Cancer. Springer; 2018.

NCCN. Rectal Cancer. Clin Pract Guidel Oncol. 2018

Glynne-Jones R, Wyrwicz L, Tiret E, Brown G, Rödel C, Cervantes A, et al. Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2017;28(July):iv22-iv40.

Velde CJH Van De, Boelens PG, Borras JM, Coebergh J, Cervantes A, Blomqvist L, et al. EURECCA colorectal : Multidisciplinary management : European consensus conference colon & rectum. 2014

K.Libutti S, G.willet C, B.Saltz L. Cancer of the Rectum. In: T.Devita V, S.Lawrence T, A.Rosenberg S, editors. Cancer Principles & Practice of Oncology. 9th ed. Philadelphia: LIPPINCOTT WILLIAMS & WILKINS; 2011.

M.Liu M, G.willet C, G.CZito B. Cancer of the Colon and Rectum. In: Halperin EC, Wazer DE, A.Perez C, W.Brady L, editors. Principles and Practice of Radiation Oncology. 6th ed. Philadelphia: LIPPINCOTT WILLIAMS & WILKINS; 2013. p. 1215–31.

D.Minsky B, M.Rodel C, Valentini V. Rectal Cancer. In: Gunderson LL, Joel E. Tepper, editors. Clinical Radiation Oncology. 4th ed. Philadelphia: elsevier; 2016. p. 992–1018.

Fleming M, Ravula S, Tatishchev SF, Wang HL. Colorectal carcinoma: Pathologic aspects. J Gastrointest Oncol. 2012;3(3):153–73.

Jhaveri KS, Hosseini-Nik H. MRI of rectal cancer: An overview and update on recent advances. Am J Roentgenol. 2015;205(1):W42–55.

Ramli I, Gondhowiardjo S, Dhamiyati W. Radiation Treatment in Rectal Cancer: Indonesian Perspective. In: Sudoyo AW, Gondhowiardjo S, Hutagallung EU, Panegoro SS, Phillipi B, Sekarutami SM. The Multidisciplinary Cancer Management of Solid Tumors: Breast, Colorectal and The Sarcomas Today and Tomorrow. Jakarta: The Information and Publication Center of the Department of Internal Medicini, University of Indonesia, Faculty of Medicine; 2004. p.73-82.

Rödel C, Wittekind C, Fietkau R, Martus P, Ph D, Tschmelitsch J, et al. Preoperative versus Postoperative Chemoradiotherapy for Rectal Cancer. N Engl J Med [Internet]. 2004;351:1731–40. Available from: https://www.nejm.org/doi/full/10.1056/NEJMoa040694

R- N, Roh MS, Colangelo LH, Connell MJO, Yothers G, Deutsch M, et al. J OURNAL OF C LINICAL O NCOLOGY Preoperative Multimodality Therapy Improves Disease-Free Survival in Patients With Carcinoma of the Rectum : 2009;27(31).

Gondhowiardjo S, Pusponegoro AD. The Role of Irradiation in The Treatment of Rectal Cancer. A Literature Review and Some Experience. In: Berkel H, Kresno SB, Susworo R, eds. Book of Proceeding Jakarta International Cancer Conference '95. Jakarta: Gaya Baru: 1997; 342-8.

Shukla NH, Seenu V, Goel AK, Deo SVS, Lal P. et al. Cancer of The Colon, Rectum and Anal Canal. In: Rath GK, Mohanti BK, eds. Textbook of Radiation Oncology Principles and Practice. New Delhy: Churchill. Livingstone: 2000; 407-43.

Lavery IC, Lopez-Kostner F, Peley RJ, Fine RM. Multidiciplinary Approach to Cancer. Treatment of Colon and Rectal CAncer. Survg Clin of North America 2001;15:1-8.

Taylor FGM, Quirke P, Heald RJ, Moran BJ, Blomqvist L, Swift IR, et al. Preoperative magnetic resonance imaging assessment of circumferential resection margin predicts disease-free survival and local recurrence: 5-Year follow-up results of the MERCURY Study. J Clin Oncol. 2014;32(1):34–43.

Swedish Rectal Cancer Trial. Improved Survival with Preoperative Radiotherapy in Resectable Rectal Cancer. N Engl J Med [Internet]. 1997;336:980–7. Available from: https://www.nejm.org/doi/full/10.1056/NEJM199704033361402

Kapiteijn E, Marijnen CAM, Nagtegaal I, Putter H, Steup WH, Wiggers T, et al. Preoperative Radiotherapy Combined with Total Mesorectal Excision fot Resectable Rectal Cancer. N Engl J Med. 2001;345(9):638–46.

Bujko K, Nowacki MP, Nasierowska-Guttmejer A, Michalski W, Bebenek M, Kryj M. Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer. Br J Surg. 2006;93(10):1215–23.

Solomon M, Alfred RP, Ngan SY, Burmeister B, Fisher RJ, Solomon M, et al. JOURNAL OF CLINICAL ONCOLOGY Randomized Trial of Short-Course Radiotherapy Versus Long-Course Chemoradiation Comparing Rates of Local Recurrence in Patients With T3 Rectal Cancer : Trans-Tasman Radiation Oncology Group Trial 01 . 04. 2012;30(31):3827–33.

Erlandsson J, Holm T, Pettersson D, Berglund Å, Cedermark B, Radu C, et al. Optimal fractionation of preoperative radiotherapy and timing to surgery for rectal cancer ( Stockholm III ): a multicentre , randomised , non-blinded , phase 3 , non-inferiority trial. (Stockholm III).

Habr-gama A, Gama-rodrigues J, Proscurshim I, Sabbagh C, Sa GP, Lynn PB, et al. Local Recurrence After Complete Clinical Response and Watch and Wait in Rectal Cancer After Neoadjuvant Chemoradiation : Impact of Salvage Therapy on Local Disease Control. 2014;

Renehan AG, Malcomson L, Emsley R, Gollins S, Maw A, Myint AS, et al. Watch-and-wait approach versus surgical resection after chemoradiotherapy for patients with rectal cancer ( the OnCoRe project ): a propensity-score matched cohort analysis. Lancet Oncol [Internet]. 2015;2045(15):1–10. Available from: http://dx.doi.org/10.1016/S1470-2045(15)00467-2




DOI: https://doi.org/10.32532/jori.v10i1.97 <

Article metrics

Abstract views : 552 | views : 334

Refbacks

  • Saat ini tidak ada refbacks.




  

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.